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Abstract

Introduction: Various parts of this plant have a variety of important minerals, are a great source of vitamins, B carotene, protein, and amino acids, and can raise hemoglobin levels. Additionally, they share the same potential for preventing anemia in pregnant women as folic acid and iron supplements. Contrary to popular belief, Moringa oleifera leaves were commonly used as an abortifacient and to avoid unneeded pregnancy in the first trimester. After administering 100 mg/kg of the alcoholic extract, 100% of the rats miscarried. Contrarily, the alcohol extract, when administered at doses of 50 and 25 mg/kg body weight, respectively, resulted in abortion rates of 44.86% and 26.26%. This study intends to evaluate the teratogenic potential of moringa seed extract, its phytochemistry, and its effects on the uterus, hepar, and kidneys of pregnant mice.


Methods: Twenty-four pregnant female Balb/c mice were used in the experiment. Four groups were created from a random selection of them. Group K is allowed to have food and drinks at no cost. The doses of 10, 20, and 30 mg/kg bb of moringa seed or stem extract were given to Group P1–P3 after 7–18 days of pregnancy. On day 19, a Cesar surgery was done to remove the uterus and count the number of fetuses that were alive and dead, as well as any disabilities and other morphological abnormalities. Phytochemicals are the subject of both quantitative and qualitative investigation. The kidneys and hepar are also removed in order to look for signs of organ degradation.


Results and discussions: No absorption or abortion occurred during this experiment. The endometrium and myometrium's histological appearance showed mild epithelial destruction, uterine gland damage, and inflammatory cell infiltration. The comparisons between K and P2, K and P3, and P1 and P3 were significantly compared. There was significant damage in the histopathological appearance. The comparisons between K and P2, K and P3 were significantly compared. Histopathology slide found necrosis and degeneration, especially hydropic degeneration and infiltration in lymphocytes and erythrocytes in the microscopic description of mice's kidneys. The comparisons between K and P1, K and P2, and K and P3 were significantly compared. Qualitative Phytochemical Tests on seeds and stems contained Alkaloids, Flavonoids, Phenolics, Tannins, and Steroids. The stems, roots, and flowers of M. oleifera may contain phytochemical elements that might be detrimental, particularly during pregnancy


Conclusion: In conclusion, the ethanol extract of Moringa seed does not exhibit any impact on the uterus. However, it does induce microdamage and inflammation in the kidney and liver.

Keywords

Moringa Seeds, Teratogenic, Phytochemical Analysis

Article Details

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