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Abstract

Breast cancer is the most common diagnosed cancer worldwide with total 2.3 million cases. Impaired apoptosis plays a central role in the development of breast cancer and can reduces the efficacy of traditional cytotoxic therapies. Ficus deltoidea Jack containing many beneficial chemical compounds especially vitexin, isovitexin, moretenol, luteolin, vicenin-2 and orientin which established anticancer effect. The aim of study was to investigate breast cancer activity of Ficus deltoidea Jack six bioactive compounds specifically on apoptosis using computational study. PASS (Prediction of Activity Spectra for Substances) was used to analyze the bioactive compounds. The analysis continues with an insilico study on protein Bcl-2 and Caspase



  1. From molecular docking moretenol had highest docking score on Bcl 2 ( -7,99 kcal/mol) and caspase 3 (- 7,6 kcal/mol) compared to vitexin, isovitexin, luteolin, vicenin-2 and orientin. Based on PASS analysis, isovitexin, vitexin, orientin, luteolin and vicenin-2 could enhance TP53 gene expression which encodes the p53 tumor suppressor protein that is pivotal in apoptosis, while moretenol had activity as caspase 3 stimulant. These results can be a reference for further study whether in vitro or in vivo.


 

Keywords

Apoptosis, Breast Cancer, Ficus deltoidea

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References

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