Main Article Content
Abstract
Background: Alzheimer's disease (AD) is the leading cause of dementia worldwide, imposing a significant economic burden on patients and society. While existing literature has confirmed the effectiveness of exercise as a non-pharmacological intervention for AD, there remains a lack of bibliometric studies focused on AD exercise research. To address this gap, this paper aims to provide an insightful analysis of the growth in AD exercise literature published from 2014 to 2023, using bibliometrics to offer historical insights for the scientific research community. Objective: This study's primary objective is to analyse the expansion of AD exercise literature through bibliometric methods, shedding light on historical trends and their significance in scientific research. Methods: A total of 1,552 documents were retrieved by conducting a title search on the Scopus database, utilizing Boolean operators "OR" and "AND" with keywords related to "exercise" and "Alzheimer's disease." Comprehensive bibliometric analysis was carried out using Microsoft Excel and VOSviewer, encompassing various factors such as countries, institutions, authors, and keyword terms. Results: A noteworthy Randomized Controlled Trial (RCT) conducted in 2015, investigating the impact of factors, including diet and exercise, on cognitive decline in the elderly, emerged as the most influential article in the field, with an impressive 1,955 citations, underscoring its substantial impact and recognition within the scientific community. The year 2020 marked a remarkable increase in the publication of AD exercise-related articles, with a total of 206 papers being published. Conclusion: In the future, it is essential to explore the effectiveness and feasibility of multi-mode interventions that promote an active lifestyle, including exercise, across diverse global populations and settings. This study, by providing a global overview, tracing thematic evolution, and spotlighting future research trends in the AD exercise domain, serves as a guiding reference for future research endeavours in this field.
Keywords
Article Details
References
- Alzheimer’s Association. (2021). 2021 Alzheimer’s disease facts and figures. Alzheimer’s and Dementia, 17(3), 327–406. doi: 10.1002/ALZ.12328
- Alty, J., Farrow, M., & Lawler, K. (2020). Exercise and dementia prevention. Practical Neurology, 20(3), 234–240. doi: 10.1136/PRACTNEUROL-2019-002335
- Andrieu, S., Guyonnet, S., Coley, N., Cantet, C., Bonnefoy, M., Bordes, S., Bories, L., Cufi, M. N., Dantoine, T., Dartigues, J. F., Desclaux, F., Gabelle, A., Gasnier, Y., Pesce, A., Sudres, K., Touchon, J., Robert, P., Rouaud, O., Legrand, P., … Olivier-Abbal, P. (2017). Effect of long-term omega 3 polyunsaturated fatty acid supplementation with or without multidomain intervention on cognitive function in elderly adults with memory complaints (MAPT): a randomised, placebo- controlled trial. The Lancet Neurology, 16(5), 377–389. doi: 10.1016/S1474-
- (17)30040-6
- Arvanitakis, Z., Shah, R. C., & Bennett, D. A. (2019). Diagnosis and Management of Dementia: Review. JAMA - Journal of the American Medical Association, 322(16), 1589–1599. doi: 10.1001/JAMA.2019.4782
- Baber, R. J., Panay, N., & Fenton, A. (2016). 2016 IMS Recommendations on womens midlife health and menopause hormone therapy. Climacteric, 19(2), 109–150. doi: 10.3109/13697137.2015.1129166
- Baumgart, M., Snyder, H. M., Carrillo, M. C., Fazio, S., Kim, H., & Johns, H. (2015). Summary of the evidence on modifiable risk factors for cognitive decline and dementia: A population- based perspective. Alzheimer’s and Dementia, 11(6), 718–726. doi:
- 1016/J.JALZ.2015.05.016
- Beydoun, M. A., Beydoun, H. A., Gamaldo, A. A., Teel, A., Zonderman, A. B., & Wang, Y. (2014). Epidemiologic studies of modifiable factors associated with cognition and dementia: Systematic review and meta- analysis. BMC Public Health, 14(1). doi: 10.1186/1471-2458-14-643
- Choi, S. H., Bylykbashi, E., Chatila, Z. K., Lee, S.
- W., Pulli, B., Clemenson, G. D., Kim, E.,
- Rompala, A., Oram, M. K., Asselin, C., Aronson, J., Zhang, C., Miller, S. J., Lesinski, A., Chen, J. W., Kim, D. Y., Van Praag, H., Spiegelman, B. M., Gage, F. H., & Tanzi, R.
- E. (2018). Combined adult neurogenesis and BDNF mimic exercise effects on cognition in an Alzheimer’s mouse model. Science, 361(6406). doi:
- 1126/SCIENCE.AAN8821
- Donthu, N., Kumar, S., Mukherjee, D., Pandey, N., & Lim, W. M. (2021). How to conduct a bibliometric analysis: An overview and guidelines. Journal of Business Research,
- , 285–296. doi:
- 1016/J.JBUSRES.2021.04.070
- Iso-Markku, P., Kujala, U. M., Knittle, K., Polet, J., Vuoksimaa, E., & Waller, K. (2022). Physical activity as a protective factor for dementia and Alzheimer’s disease: systematic review, meta- analysis and quality assessment of cohort and case-control studies. British Journal of Sports Medicine, 56(12), 701–709. doi: 10.1136/BJSPORTS-2021-104981
- Keene, C. D., & Montine, T. J. (2022, August 23). Epidemiology, pathology, and pathogenesis of Alzheimer disease. UpToDate. Retrieved from https://www.uptodate.com/contents/epidemio logy-pathology-and-pathogenesis-of- alzheimer-disease
- López-Ortiz, S., Pinto-Fraga, J., Valenzuela, P. L., Martín-Hernández, J., Seisdedos, M. M., García-López, O., Toschi, N., Di Giuliano, F., Garaci, F., Mercuri, N. B., Nisticò, R., Emanuele, E., Lista, S., Lucia, A., & Santos- Lozano, A. (2021). Physical Exercise and Alzheimer’s Disease: Effects on Pathophysiological Molecular Pathways of the Disease. International Journal of Molecular Sciences, 22(6), 1–29. doi: 10.3390/IJMS22062897
- López-Ortiz, S., Valenzuela, P. L., Seisdedos, M. M., Morales, J. S., Vega, T., Castillo-García, A., Nisticò, R., Mercuri, N. B., Lista, S., Lucia, A., & Santos-Lozano, A. (2021). Exercise interventions in Alzheimer’s disease: A systematic review and meta-analysis of randomized controlled trials. Ageing Research Reviews, 72, 101479. doi: 10.1016/J.ARR.2021.101479
- Marasco, R. A. (2020). Economic burden of Alzheimer disease and managed care considerations. The American Journal of Managed Care, 26(8 Suppl), S171–S183. doi: 10.37765/AJMC.2020.88482
- Mejia, C., Wu, M., Zhang, Y., & Kajikawa, Y. (2021). Exploring Topics in Bibliometric Research Through Citation Networks and Semantic Analysis. Frontiers in Research Metrics and Analytics, 6, 742311. doi: 10.3389/FRMA.2021.742311
- Ngandu, T., Lehtisalo, J., Solomon, A., Levälahti, E., Ahtiluoto, S., Antikainen, R., Bäckman, L., Hänninen, T., Jula, A., Laatikainen, T., Lindström, J., Mangialasche, F., Paajanen, T., Pajala, S., Peltonen, M., Rauramaa, R., Stigsdotter-Neely, A., Strandberg, T., Tuomilehto, J., … Kivipelto, M. (2015). A 2 year multidomain intervention of diet, exercise, cognitive training, and vascular risk monitoring versus control to prevent cognitive
- decline in at-risk elderly people (FINGER): A randomised controlled trial. The Lancet, 385(9984), 2255–2263. doi: 10.1016/S0140-
- (15)60461-5
- Rajan, K. B., Weuve, J., Barnes, L. L., McAninch,
- E. A., Wilson, R. S., & Evans, D. A. (2021).
- Population Estimate of People with Clinical AD and Mild Cognitive Impairment in the United States (2020–2060). Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association, 17(12), 1966. doi: 10.1002/ALZ.12362
- Rinninella, E., Raoul, P., Cintoni, M., Franceschi, F., Miggiano, G. A. D., Gasbarrini, A., & Mele, M. C. (2019). What is the healthy gut microbiota composition? A changing ecosystem across age, environment, diet, and diseases. Microorganisms, 7(1). doi: 10.3390/MICROORGANISMS7010014
- Ross, R., Blair, S. N., Arena, R., Church, T. S., Després, J. P., Franklin, B. A., Haskell, W. L., Kaminsky, L. A., Levine, B. D., Lavie, C. J., Myers, J., Niebauer, J., Sallis, R., Sawada, S. S., Sui, X., & Wisløff, U. (2016). Importance of Assessing Cardiorespiratory Fitness in Clinical Practice: A Case for Fitness as a Clinical Vital Sign: A Scientific Statement from the American Heart Association. Circulation, 134(24), e653–e699. doi: 10.1161/CIR.0000000000000461
- Rousseau, R., Garcia-Zorita, C., & Sanz-Casado, E. (2023). Publications during COVID-19 times: An unexpected overall increase. Journal of Informetrics, 17(4), 101461. doi: 10.1016/J.JOI.2023.101461
- Shvindina, H. (2019). Coopetition as an emerging trend in research: Perspectives for safety & security. Safety, 5(3). doi: 10.3390/SAFETY5030061
- Skaria, A. P. (2022). The Economic and Societal Burden of AlzheimerDisease: Managed Care Considerations. American Journal of Managed Care, 28, S188–S196. doi: 10.37765/AJMC.2022.89236
- WHO. (2023). Dementia. WHO Fact Sheets. Retrieved from https://www.who.int/news- room/fact-sheets/detail/dementia
- Yu, F., Vock, D. M., Zhang, L., Salisbury, D.,
- Nelson, N. W., Chow, L. S., Smith, G., Barclay, T. R., Dysken, M., & Wyman, J. F. (2021). Cognitive Effects of Aerobic Exercise in Alzheimer’s Disease: A Pilot Randomized Controlled Trial. Journal of Alzheimer’s Disease: JAD, 80(1), 233–244. doi: 10.3233/JAD-20110
References
Alzheimer’s Association. (2021). 2021 Alzheimer’s disease facts and figures. Alzheimer’s and Dementia, 17(3), 327–406. doi: 10.1002/ALZ.12328
Alty, J., Farrow, M., & Lawler, K. (2020). Exercise and dementia prevention. Practical Neurology, 20(3), 234–240. doi: 10.1136/PRACTNEUROL-2019-002335
Andrieu, S., Guyonnet, S., Coley, N., Cantet, C., Bonnefoy, M., Bordes, S., Bories, L., Cufi, M. N., Dantoine, T., Dartigues, J. F., Desclaux, F., Gabelle, A., Gasnier, Y., Pesce, A., Sudres, K., Touchon, J., Robert, P., Rouaud, O., Legrand, P., … Olivier-Abbal, P. (2017). Effect of long-term omega 3 polyunsaturated fatty acid supplementation with or without multidomain intervention on cognitive function in elderly adults with memory complaints (MAPT): a randomised, placebo- controlled trial. The Lancet Neurology, 16(5), 377–389. doi: 10.1016/S1474-
(17)30040-6
Arvanitakis, Z., Shah, R. C., & Bennett, D. A. (2019). Diagnosis and Management of Dementia: Review. JAMA - Journal of the American Medical Association, 322(16), 1589–1599. doi: 10.1001/JAMA.2019.4782
Baber, R. J., Panay, N., & Fenton, A. (2016). 2016 IMS Recommendations on womens midlife health and menopause hormone therapy. Climacteric, 19(2), 109–150. doi: 10.3109/13697137.2015.1129166
Baumgart, M., Snyder, H. M., Carrillo, M. C., Fazio, S., Kim, H., & Johns, H. (2015). Summary of the evidence on modifiable risk factors for cognitive decline and dementia: A population- based perspective. Alzheimer’s and Dementia, 11(6), 718–726. doi:
1016/J.JALZ.2015.05.016
Beydoun, M. A., Beydoun, H. A., Gamaldo, A. A., Teel, A., Zonderman, A. B., & Wang, Y. (2014). Epidemiologic studies of modifiable factors associated with cognition and dementia: Systematic review and meta- analysis. BMC Public Health, 14(1). doi: 10.1186/1471-2458-14-643
Choi, S. H., Bylykbashi, E., Chatila, Z. K., Lee, S.
W., Pulli, B., Clemenson, G. D., Kim, E.,
Rompala, A., Oram, M. K., Asselin, C., Aronson, J., Zhang, C., Miller, S. J., Lesinski, A., Chen, J. W., Kim, D. Y., Van Praag, H., Spiegelman, B. M., Gage, F. H., & Tanzi, R.
E. (2018). Combined adult neurogenesis and BDNF mimic exercise effects on cognition in an Alzheimer’s mouse model. Science, 361(6406). doi:
1126/SCIENCE.AAN8821
Donthu, N., Kumar, S., Mukherjee, D., Pandey, N., & Lim, W. M. (2021). How to conduct a bibliometric analysis: An overview and guidelines. Journal of Business Research,
, 285–296. doi:
1016/J.JBUSRES.2021.04.070
Iso-Markku, P., Kujala, U. M., Knittle, K., Polet, J., Vuoksimaa, E., & Waller, K. (2022). Physical activity as a protective factor for dementia and Alzheimer’s disease: systematic review, meta- analysis and quality assessment of cohort and case-control studies. British Journal of Sports Medicine, 56(12), 701–709. doi: 10.1136/BJSPORTS-2021-104981
Keene, C. D., & Montine, T. J. (2022, August 23). Epidemiology, pathology, and pathogenesis of Alzheimer disease. UpToDate. Retrieved from https://www.uptodate.com/contents/epidemio logy-pathology-and-pathogenesis-of- alzheimer-disease
López-Ortiz, S., Pinto-Fraga, J., Valenzuela, P. L., Martín-Hernández, J., Seisdedos, M. M., García-López, O., Toschi, N., Di Giuliano, F., Garaci, F., Mercuri, N. B., Nisticò, R., Emanuele, E., Lista, S., Lucia, A., & Santos- Lozano, A. (2021). Physical Exercise and Alzheimer’s Disease: Effects on Pathophysiological Molecular Pathways of the Disease. International Journal of Molecular Sciences, 22(6), 1–29. doi: 10.3390/IJMS22062897
López-Ortiz, S., Valenzuela, P. L., Seisdedos, M. M., Morales, J. S., Vega, T., Castillo-García, A., Nisticò, R., Mercuri, N. B., Lista, S., Lucia, A., & Santos-Lozano, A. (2021). Exercise interventions in Alzheimer’s disease: A systematic review and meta-analysis of randomized controlled trials. Ageing Research Reviews, 72, 101479. doi: 10.1016/J.ARR.2021.101479
Marasco, R. A. (2020). Economic burden of Alzheimer disease and managed care considerations. The American Journal of Managed Care, 26(8 Suppl), S171–S183. doi: 10.37765/AJMC.2020.88482
Mejia, C., Wu, M., Zhang, Y., & Kajikawa, Y. (2021). Exploring Topics in Bibliometric Research Through Citation Networks and Semantic Analysis. Frontiers in Research Metrics and Analytics, 6, 742311. doi: 10.3389/FRMA.2021.742311
Ngandu, T., Lehtisalo, J., Solomon, A., Levälahti, E., Ahtiluoto, S., Antikainen, R., Bäckman, L., Hänninen, T., Jula, A., Laatikainen, T., Lindström, J., Mangialasche, F., Paajanen, T., Pajala, S., Peltonen, M., Rauramaa, R., Stigsdotter-Neely, A., Strandberg, T., Tuomilehto, J., … Kivipelto, M. (2015). A 2 year multidomain intervention of diet, exercise, cognitive training, and vascular risk monitoring versus control to prevent cognitive
decline in at-risk elderly people (FINGER): A randomised controlled trial. The Lancet, 385(9984), 2255–2263. doi: 10.1016/S0140-
(15)60461-5
Rajan, K. B., Weuve, J., Barnes, L. L., McAninch,
E. A., Wilson, R. S., & Evans, D. A. (2021).
Population Estimate of People with Clinical AD and Mild Cognitive Impairment in the United States (2020–2060). Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association, 17(12), 1966. doi: 10.1002/ALZ.12362
Rinninella, E., Raoul, P., Cintoni, M., Franceschi, F., Miggiano, G. A. D., Gasbarrini, A., & Mele, M. C. (2019). What is the healthy gut microbiota composition? A changing ecosystem across age, environment, diet, and diseases. Microorganisms, 7(1). doi: 10.3390/MICROORGANISMS7010014
Ross, R., Blair, S. N., Arena, R., Church, T. S., Després, J. P., Franklin, B. A., Haskell, W. L., Kaminsky, L. A., Levine, B. D., Lavie, C. J., Myers, J., Niebauer, J., Sallis, R., Sawada, S. S., Sui, X., & Wisløff, U. (2016). Importance of Assessing Cardiorespiratory Fitness in Clinical Practice: A Case for Fitness as a Clinical Vital Sign: A Scientific Statement from the American Heart Association. Circulation, 134(24), e653–e699. doi: 10.1161/CIR.0000000000000461
Rousseau, R., Garcia-Zorita, C., & Sanz-Casado, E. (2023). Publications during COVID-19 times: An unexpected overall increase. Journal of Informetrics, 17(4), 101461. doi: 10.1016/J.JOI.2023.101461
Shvindina, H. (2019). Coopetition as an emerging trend in research: Perspectives for safety & security. Safety, 5(3). doi: 10.3390/SAFETY5030061
Skaria, A. P. (2022). The Economic and Societal Burden of AlzheimerDisease: Managed Care Considerations. American Journal of Managed Care, 28, S188–S196. doi: 10.37765/AJMC.2022.89236
WHO. (2023). Dementia. WHO Fact Sheets. Retrieved from https://www.who.int/news- room/fact-sheets/detail/dementia
Yu, F., Vock, D. M., Zhang, L., Salisbury, D.,
Nelson, N. W., Chow, L. S., Smith, G., Barclay, T. R., Dysken, M., & Wyman, J. F. (2021). Cognitive Effects of Aerobic Exercise in Alzheimer’s Disease: A Pilot Randomized Controlled Trial. Journal of Alzheimer’s Disease: JAD, 80(1), 233–244. doi: 10.3233/JAD-20110