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Abstract

Vulva tumors are neoplasms of the vulva that occur in small percentage (3%) of female genital cancers which can be benign or malignant or vulva cancer. Vulva neoplasms are divided into cystic or solid lesions and other mixed types. The most common benign tumors of the vulva are fibromas, papillomas, lipomas, angiomas, and others. A young woman, 25 years old, came to Bintang Amin Hospital OBGYN clinic, complaining of a huge mass in the front area of left labia major from one year before. She never had any examination before and felt the mass become larger and caused pain and obstacle in her daily activity. We found a huge pedunculated tumor, size 9 x 6 x 1.5 cm. After excision and pathological examination, we diagnosed the patient with benign neurofibroma and suggested follow up if another lesion or tumor occur.

Keywords

Vulva tumour, Rare disease, Neurofibroma

Article Details

References

  1. Gordon MD, Weilert M, Ireland K. Plexiform neurofibromatosis involving the uterine cervix, endometrium, myometrium, and ovary. Obstet Gynecol 1996;88:699-701.
  2. Burger PC, Scheithauer BW, Vogel FS. Surgical Pathology of the Nervous System and Its Covering vol 1, 4th edn. Philadelphia: Churchill Livingstone 2002:594–611.
  3. Tamer E, Yalein B, Alli N. Multiple nodular plexiformneurofibromas in a neurofibromatosis1 family: A familial tendency? A case report and review of the literature. Int J Dermatol 2003;42:357–8.Finkel G, Lane B. 2019. Granular cell variant of neurofibromatosis: ultrastructure of benign and malignant tumors. Hum Pathol. 13(10):959-63.
  4. Mourali M, Hammedi N, Fekih C, Essoussi-Chikhaoui J, Binous N, Ben Zineb S, et al. Vaginal neurofibroma. Tunis Med 2009; 87: 411.
  5. Raffensperger J, Cohen R. 2020. Plexiform neurofibromas in childhood. J Pediatr Surg.;7(2):144-51.
  6. Ros Briones, R., Arredondo Montero, J., Bronte Anaut, M., Hernández-Martín, S., & Guarch Troyas, R. (2023). Pediatric Vulvar Superficial Angiomyxoma: A Case Report With Clinical, Radiological, and Anatomopathological Characterization and a Comprehensive Review of the Literature. International Journal of Surgical Pathology, 31(5), 852-860.
  7. O'Brien, K. L. O. F., Cortes-Santiago, N., Patil, N. M., & Bercaw-Pratt, J. L. (2020). A rare case of vulvar superficial angiomyxoma in a pediatric patient. Journal of Pediatric and Adolescent Gynecology, 33(6), 727- 729.
  8. Haroon, S., Irshad, L., Zia, S., Ali, A. H., Dowlah, T. U., Rashid, K., ... & Khan, A. (2022). Aggressive Angiomyxoma, Angiomyofibroblastoma, and Cellular Angiofibroma of the Lower Female Genital Tract: Related Entities With Different Outcomes. Cureus, 14(9).
  9. Dobrică, E. C., Vâjâitu, C., Condrat, C. E., Crețoiu, D., Popa, I., Gaspar, B. S., ... & Varlas, V. N. (2021). Vulvar and vaginal melanomas—the darker shades of gynecological cancers. Biomedicines, 9(7), 758.
  10. Harder A, Wesemann M, Hagel C, Schittenhelm J, Fischer S, Tatagiba M, Nagel C, Jeibmann A, Bohring A, Mautner VF, Paulus W. 2022. Hybrid neurofibroma/schwannoma is overrepresented among schwannomatosis and neurofibromatosis patients. Am J Surg Pathol.;36(5):702-9.
  11. Sims, S. M., Stinson, K., McLean, F. W., Davis, J. D., & Wilkinson, E. J. (2012). Angiomyofibroblastoma of the vulva: a case report of a pedunculated variant and review of the literature. Journal of Lower Genital Tract Disease, 16(2), 149-154.
  12. Hornick JL. 2019. Limited biopsies of soft tissue tumors: the contemporary role of immunohistochemistry and molecular diagnostics. Mod Pathol ;32(Suppl 1):27-37.
  13. Sims SM, Stinson K, McLean FW, Davis JD, Wilkinson EJ. Angiomyofibroblastoma of the vulva: a case report of a pedunculated variant and review of the literature. J Low Genit Tract Dis. 2012 Apr;16(2):149-54.
  14. Baulies S, Cusidó MT, Grases PJ, Ubeda B, Pascual MA, Fábregas R. Neurofibroma of the vaginal wall. Clin Exp Obstet Gynecol. 2008;35(2):140-3.
  15. Nibhoria S, Kaur Tiwana K, Kaur M, Phutela R. Isolated Vaginal Neurofibroma Presenting as Vaginal Wall Cyst: A Rare Case Report With Review of Literature. J Family Reprod Health. 2016 Mar;10(1):49-51.
  16. Sharma JB, Wadhwa L, Malhotra M, Arora R, Garg A, Singh S. Huge localized vaginal neurofibromatosis: an unusual cause of postmenopausal bleeding. J Obstet Gynaecol Res. 2004 Apr;30(2):96-9.
  17. Gómez-Laencina AM, Martínez Díaz F, Izquierdo Sanjuanes B, Vicente Sánchez EM, Fernandez Salmerón R, Meseguer Peña F. Localized neurofibromatosis of the female genital system: a case report and review of the literature. J Obstet Gynaecol Res. 2012 Jun;38(6):953-6.
  18. Işık E, Onay H, Atik T, Solmaz AE, Özen S, Çoğulu Ö, Darcan Ş, Özkınay F. A Neurofibromatosis Noonan Syndrome Patient Presenting with Abnormal External Genitalia. J Clin Res Pediatr Endocrinol. 2020 Mar 19;12(1):113-116.
  19. Lee TJ, Chopra M, Kim RH, Parkin PC, Barnett-Tapia C. Incidence and prevalence of neurofibromatosis type 1 and 2: a systematic review and meta-analysis. Orphanet J Rare Dis. 2023 Sep 14;18(1):292.
  20. Legius E, Messiaen L, Wolkenstein P, Pancza P, Avery RA, Berman Y, Blakeley J, Babovic-Vuksanovic D, Cunha KS, Ferner R, Fisher MJ, Friedman JM, Gutmann DH, Kehrer-Sawatzki H, Korf BR, Mautner VF, Peltonen S, Rauen KA, Riccardi V, Schorry E, Stemmer- Rachamimov A, Stevenson DA, Tadini G, Ullrich NJ, Viskochil D, Wimmer K, Yohay K; International Consensus Group on Neurofibromatosis Diagnostic Criteria (I-NF-DC); Huson SM, Evans DG, Plotkin SR. Revised diagnostic criteria for neurofibromatosis type1 and Legius syndrome: an international consensus recommendation. Genet Med. 2021 Aug;23(8):1506- 1513.