Main Article Content
Abstract
Human Immunodeficiency Virus (HIV) infection is a high-risk factor for the development of TB cases. TB and HIV co-infection is a problem with case rates globally and in Indonesia still high. Information regarding characteristics such as age, gender, and laboratory results including hemoglobin levels and CD4 cell counts is needed to support prevention and treatment programs for TB/HIV co-infection. This research aims to determine the description of the laboratory results of TB-HIV/AIDS co-infection sufferers at Dr.Mohammad Hoesin Hospital, Palembang for the period May 2022-May 2023. This research uses descriptive observational research by observing medical record data and laboratory data at Dr. Mohammad Hoesin Hospital. Mohammad Hoesin Palembang who met the inclusion criteria. The number of TB-HIV co-infection sufferers found at Dr. Mohammad Hoesin Palembang received 42 cases. The prevalence of sufferers is predominantly male (66%). Based on age, most were found at the age of 30-40 years (47.6%). From the results of the CD4 cell examination, most patients had a CD4 cell count <100 cells/mm3 (69%). Examination of hemoglobin levels was dominated by patients with low hemoglobin levels, namely (71.4%). The majority of cases of TB-HIV/AIDS co-infection at RSUP Dr. Mohammad Hoesin Palembang for the period May 2022-May 2023 is male, aged 30-40 years , has a CD4 cell count <100 cells/mm3, low hemoglobin level (<13 (L)/ <12(P) g/dl).
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References
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- World Health Organization. 2023. HIV. Available from:
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References
Vaillant AJ, Gulick P. 2022. Current HIV disease practice. 1–9. Available from: https://www-ncbi-nlm-nih- gov.translate.goog/books/NBK 5348
World Health Organization. 2023. HIV. Available from:
https://www.who.int/data/gho/data/themes/ hiv-aids#cms
World Health Organization. 2023. Global Tuberculosis Report 2022 [Internet]. Available from: www.who.int › global- tuberculosis-report-2022
Indonesian TB. 2023. TB situation in Indonesia. [Internet]. Available from: https://tbindonesia.or.id/pustaka- tbc/dashboard/
WHO. 2021. Global Tuberculosis 2021.
Hamada Y, Getahun H, Tadesse BT, Ford N. 2021. HIV-associated tuberculosis. Int J STD AIDS.;32(9):780–90.
Ibrahim K, H YK, Rahayuwati L, Nurmalisa BE. 2017. Correlation between Fatigue, CD4 Cell Count, and Hemoglobin Level in Patients Infected with Human Immunodeficiency Virus (HIV) The Correlation of Between Fatigue, CD4 Cell Count, and Hemoglobin Level among HIV/AIDS Patients. Jkp. 5(3):271–80.
Vijayan KV, Karthigeyan KP, Tripathi SP, Hanna LE. 2017. Pathophysiology of CD4+ T-Cell depletion in HIV-1 and HIV- 2 infections. Front Immunol.;8(MAY):1–8.
Meintjes G, Brust JCM, Nuttall J, Maartens G. 2019. Management of active tuberculosis in
adults with HIV. Lancet HIV [Internet]. 6(7):e463–74. Available from: http://dx.doi.org/10.1016/S2352- 3018(19)30154-7
Abdillah EK, Rahman RIA, Nugrahini L, Dewi LYAN. 2022. Characteristics of HIV/AIDS patients coinfected with pulmonary tuberculosis at XYZ Hospital Buleleng. Heal Sci Pharm Journal, 6(2):49–54.
Krisnahari KL, Sawitri AAS. 2018. Characteristics of HIV/AIDS Patients with Tuberculosis Coinfection at the Badung Regional General Hospital (RSUD) and the Bali Medika Clinic in Kuta. Udayana Med E-Journal [Internet]. 7(11):1. Available https://ojs.unud.ac.id/index.php/eum/article
/view/44090
Nurullah Afifah F et al. 2023. Characteristics of TB-Hiv Coinfection Patients at RSUD Dr.
H. Chasan Boesoirie Ternate 2018- 2021
Period. 694–9.
Zhou Y, Li T, Lin S, Chen D, Du Y, Chen J, et al. 2023. Characteristics and treatment outcomes of co-infected tuberculosis patients with human immunodeficiency virus in Southeast China, 2012–2021. BMC Infect Dis. 23(1):1–7.
World Health Organization. 2023. HIV AND AIDS. Available from: https://www.who.int/news-room/fact- sheets/detail/hiv-aids
Mar'iyah K, Zulkarnain. 2021. Pathophysiology of tuberculosis infection. Pros Semin Nas Biol [Internet]. 7(1):88–92. Available from: http://journal.uin- alauddin.ac.id/index.php/psb
Aulia.A, Rahayu, Fauzi P. 2021. Determinants of Changes in CD4 Levels in People with HIV-AIDS Coinfection with TB. Indonesia J Public Heal Nutr [Internet]. (1):472–8. Availablehttp://journal.unnes.ac.id/sju/in de x.php/IJPHN
P DY, Dian SD, Gayatri AY, Utama MS, Somia A, Parwati M T. 2019. Characteristics of HIV/AIDS patients with tuberculosis co- infection at the VCT polyclinic of Sanglah Hospital. Medicina (B Aires). 50(2):386– 90.
Tiewsoh, Jutang Babat Ain; Antony, Beena; Boloor R 2020. HIV-TB co-infection with clinical presentation, diagnosis, treatment, outcome and its relation to CD4 count, a cross-sectional study in a tertiary care hospital in coastal Karnataka. J Fam Med Prim Care [Internet]. 6(2):169–70. Available
from: http://www.jfmpc.com/article.asp?issn=224
Sundari ARP, Tursina A, Siddiq TB.2023. Description of the Characteristics of Tuberculosis Opportunistic Infection Patients with HIV/AIDS at Al-Ihsan Regional Hospital. Bandung Conf Ser Med Sci. 3(1):141–8.
Effendy E, Amin MM, de Vega L, Utami N. 2019. The association between CD-4 levels, stress and depression symptoms among people living with HIV/AIDS. Open Access Maced J Med Sci. 7(20):3459–63.
Yogani I, Karyadi TH, Uyainah A, Koesnoe
S. 2017. Factors Associated with Elevated CD4 in HIV Patients Who Received Highly Active Antiretroviral Therapy in the First 6 Months. J Indonesian Internal Medicine. 2(4):217.
Mulanto IL. 2022. Risk factors for tuberculosis co-infection in HIV/AIDS patients at KRMT WONGSONE- GORO Hospital, Semarang. Available from: http://repository.unissula.ac.id/25322
/1/301 0150746
de Mendonça EB, Schmaltz CAS, Sant'Anna FM, Vizzoni AG, Mendes-De-Almeida DP, de Vasconcellos Carvalhaes de Oliveira R, et al. 2021. Anemia in tuberculosis. PLOS One. 16(2 February):1–12.
Arisena Y, Silitonga M, Kurniati I, Medicine F, Lampung U, BP Clinic, et al. 2019. Tuberculosis (TBC) and Human Immunodeficiency Virus (HIV) Collaboration Tuberculosis (TBC) and Human Immunodeficiency Virus (HIV) Collaboration.9:276–84.
Massang, Benjamin EK. 2018. Relationship Between CD4 Count and Hemoglobin Levels in HIV Patients. 3(April):2–5.
Pertiwi D. 2019. The role of the MTHFR C665t gene polymorphism in the incidence of macrocytic anemia in HIV- infected patients receiving Zidovudine therapy, Case Control study in 2019;1–2. Available https://digilib.uns.ac.id/document/detail/70 895/Peran-polimorfisme-gen-MTHFR- C665t-dalam-cepat-anemia-makrositik- pada-penderita-terinfeksi-HIV-yang- mendapat -Zidovudine-therapy- Case- Control-study-on-Javanese-ethnicity