Main Article Content
Abstract
Whole grain consumption has known beneficial effects for health. However, the interplay of whole grain consumption, the human gut microbiota, and metabolic health needs to be further unraveled. This paper aims to describe the interplay of whole grain consumption and gut microbiota for metabolic health. It is a narrative literature review. The journals were selected from PubMed, Science Direct, and Google Scholar. It was found that whole grain consumption could modulate the production of short-chain fatty acids. Whole grains contain phenolic acid, flavonoids, and plant sterols. The composition, diversity, structure, and metabolites of gut microbiota might be changed by whole grain consumption. Whole grain consumption might improve glucose metabolism, enhance immune function, and reduce inflammation. Glucose intolerance and insulin resistance might be reduced. Intestinal inflammation could be alleviated. In conclusion, whole grain consumption can improve gut health, better blood glucose control, and potentially reduced inflammation.
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References
- Aslam, H., Trakman, G., Dissanayake, T., Todd, E., Harrison, P., Alby, C., Jabeen, T., Gamage, E., Travica, N., Marshall, S., Ruusunen, A., Rocks, T., Marx, W., Berk, M., O’Neil, A., McGuinness, A. J., Jennings, L., Jacka, F. N., & Dawson, S. L. (2026). Dietary interventions and the gut microbiota: A systematic literature review of 80 controlled clinical trials. Journal of Translational Medicine, 24(1), 39. https://doi.org/10.1186/s12967-025-07428-9
- Fava, F., Rizzetto, L., & Tuohy, K. M. (2019). Gut microbiota and health: Connecting actors across the metabolic system. Proceedings of the Nutrition Society, 78(02), 177–188. https://doi.org/10.1017/S0029665118002719
- Guo, Z., Zhang, J., Wang, Z., Ang, K. Y., Huang, S., Hou, Q., Su, X., Qiao, J., Zheng, Y., Wang, L., Koh, E., Danliang, H., Xu, J., Lee, Y. K., & Zhang, H. (2016). Intestinal Microbiota Distinguish Gout Patients from Healthy Humans. Scientific Reports, 6(1), 20602. https://doi.org/10.1038/srep20602
- He, J., He, Y., Li, J., Ma, G., Li, Y., Xie, J., He, C., Feng, X., Jia, K., Li, W., Wang, M., Tang, A., Tian, T., Liao, X., Li, W., Yan, F., Zhang, Y., Cao, X., Zhang, Y., … Wang, Q. (2025). Habitual coarse grain intake, gut microbiota, and hyperuricemia in individuals with or at risk of metabolic syndrome: A post-hoc analysis. Nutrition, Metabolism and Cardiovascular Diseases, 104126. https://doi.org/10.1016/j.numecd.2025.104126
- Ko, C.-Y., Liu, Q.-Q., Su, H.-Z., Zhang, H.-P., Fan, J.-M., Yang, J.-H., Hu, A.-K., Liu, Y.-Q., Chou, D., & Zeng, Y.-M. (2019). Gut microbiota in obstructive sleep apnea–hypopnea syndrome: Disease-related dysbiosis and metabolic comorbidities. Clinical Science, 133(7), 905–917. https://doi.org/10.1042/CS20180891
- Li, J., Zhao, F., Wang, Y., Chen, J., Tao, J., Tian, G., Wu, S., Liu, W., Cui, Q., Geng, B., Zhang, W., Weldon, R., Auguste, K., Yang, L., Liu, X., Chen, L., Yang, X., Zhu, B., & Cai, J. (2017). Gut microbiota dysbiosis contributes to the development of hypertension. Microbiome, 5(1), 14. https://doi.org/10.1186/s40168-016-0222-x
- Liu, H., Xu, X., Yao, Z., Kang, J., Shen, Y., & Liu, W. (2025). Association between the dietary index for gut microbiota and metabolic syndrome in adults: The mediating role of body mass index. Frontiers in Nutrition, 12, 1598664. https://doi.org/10.3389/fnut.2025.1598664
- Moreno-Indias, I., Torres, M., Montserrat, J. M., Sanchez-Alcoholado, L., Cardona, F., Tinahones, F. J., Gozal, D., Poroyko, V. A., Navajas, D., Queipo-Ortuño, M. I., & Farré, R. (2015). Intermittent hypoxia alters gut microbiota diversity in a mouse model of sleep apnoea. European Respiratory Journal, 45(4), 1055–1065. https://doi.org/10.1183/09031936.00184314
- Oda, E. (2018). Historical perspectives of the metabolic syndrome. Clinics in Dermatology, 36(1), 3–8. https://doi.org/10.1016/j.clindermatol.2017.09.002
- Ray, S., & Shankaran, P. (2026). Nutrition and the gut microbiome: A symbiotic dialogue influencing health and disease. Frontiers in Nutrition, 13, 1761992. https://doi.org/10.3389/fnut.2026.1761992
- Tomas, J., Mulet, C., Saffarian, A., Cavin, J.-B., Ducroc, R., Regnault, B., Kun Tan, C., Duszka, K., Burcelin, R., Wahli, W., Sansonetti, P. J., & Pédron, T. (2016). High-fat diet modifies the PPAR-γ pathway leading to disruption of microbial and physiological ecosystem in murine small intestine. Proceedings of the National Academy of Sciences, 113(40). https://doi.org/10.1073/pnas.1612559113
- Van Kalkeren, C. A., Adam, T. C., & Blaak, E. E. (2026). Gut Microbiome-Associated Effects of Plant-Based Diets on Glucose Homeostasis, Body Composition, and Cognitive Function: A Scoping Review. Advances in Nutrition, 17(4), 100610. https://doi.org/10.1016/j.advnut.2026.100610
- Wang, P.-X., Deng, X.-R., Zhang, C.-H., & Yuan, H.-J. (2020). Gut microbiota and metabolic syndrome. Chinese Medical Journal, 133(7), 808–816. https://doi.org/10.1097/CM9.0000000000000696
- Zhou, W., Xu, H., Zhan, L., Lu, X., & Zhang, L. (2019). Dynamic Development of Fecal Microbiome During the Progression of Diabetes Mellitus in Zucker Diabetic Fatty Rats. Frontiers in Microbiology, 10, 232. https://doi.org/10.3389/fmicb.2019.00232
- Zmora, N., Suez, J., & Elinav, E. (2019). You are what you eat: Diet, health and the gut microbiota. Nature Reviews Gastroenterology & Hepatology, 16(1), 35–56. https://doi.org/10.1038/s41575-018-0061-2
References
Aslam, H., Trakman, G., Dissanayake, T., Todd, E., Harrison, P., Alby, C., Jabeen, T., Gamage, E., Travica, N., Marshall, S., Ruusunen, A., Rocks, T., Marx, W., Berk, M., O’Neil, A., McGuinness, A. J., Jennings, L., Jacka, F. N., & Dawson, S. L. (2026). Dietary interventions and the gut microbiota: A systematic literature review of 80 controlled clinical trials. Journal of Translational Medicine, 24(1), 39. https://doi.org/10.1186/s12967-025-07428-9
Fava, F., Rizzetto, L., & Tuohy, K. M. (2019). Gut microbiota and health: Connecting actors across the metabolic system. Proceedings of the Nutrition Society, 78(02), 177–188. https://doi.org/10.1017/S0029665118002719
Guo, Z., Zhang, J., Wang, Z., Ang, K. Y., Huang, S., Hou, Q., Su, X., Qiao, J., Zheng, Y., Wang, L., Koh, E., Danliang, H., Xu, J., Lee, Y. K., & Zhang, H. (2016). Intestinal Microbiota Distinguish Gout Patients from Healthy Humans. Scientific Reports, 6(1), 20602. https://doi.org/10.1038/srep20602
He, J., He, Y., Li, J., Ma, G., Li, Y., Xie, J., He, C., Feng, X., Jia, K., Li, W., Wang, M., Tang, A., Tian, T., Liao, X., Li, W., Yan, F., Zhang, Y., Cao, X., Zhang, Y., … Wang, Q. (2025). Habitual coarse grain intake, gut microbiota, and hyperuricemia in individuals with or at risk of metabolic syndrome: A post-hoc analysis. Nutrition, Metabolism and Cardiovascular Diseases, 104126. https://doi.org/10.1016/j.numecd.2025.104126
Ko, C.-Y., Liu, Q.-Q., Su, H.-Z., Zhang, H.-P., Fan, J.-M., Yang, J.-H., Hu, A.-K., Liu, Y.-Q., Chou, D., & Zeng, Y.-M. (2019). Gut microbiota in obstructive sleep apnea–hypopnea syndrome: Disease-related dysbiosis and metabolic comorbidities. Clinical Science, 133(7), 905–917. https://doi.org/10.1042/CS20180891
Li, J., Zhao, F., Wang, Y., Chen, J., Tao, J., Tian, G., Wu, S., Liu, W., Cui, Q., Geng, B., Zhang, W., Weldon, R., Auguste, K., Yang, L., Liu, X., Chen, L., Yang, X., Zhu, B., & Cai, J. (2017). Gut microbiota dysbiosis contributes to the development of hypertension. Microbiome, 5(1), 14. https://doi.org/10.1186/s40168-016-0222-x
Liu, H., Xu, X., Yao, Z., Kang, J., Shen, Y., & Liu, W. (2025). Association between the dietary index for gut microbiota and metabolic syndrome in adults: The mediating role of body mass index. Frontiers in Nutrition, 12, 1598664. https://doi.org/10.3389/fnut.2025.1598664
Moreno-Indias, I., Torres, M., Montserrat, J. M., Sanchez-Alcoholado, L., Cardona, F., Tinahones, F. J., Gozal, D., Poroyko, V. A., Navajas, D., Queipo-Ortuño, M. I., & Farré, R. (2015). Intermittent hypoxia alters gut microbiota diversity in a mouse model of sleep apnoea. European Respiratory Journal, 45(4), 1055–1065. https://doi.org/10.1183/09031936.00184314
Oda, E. (2018). Historical perspectives of the metabolic syndrome. Clinics in Dermatology, 36(1), 3–8. https://doi.org/10.1016/j.clindermatol.2017.09.002
Ray, S., & Shankaran, P. (2026). Nutrition and the gut microbiome: A symbiotic dialogue influencing health and disease. Frontiers in Nutrition, 13, 1761992. https://doi.org/10.3389/fnut.2026.1761992
Tomas, J., Mulet, C., Saffarian, A., Cavin, J.-B., Ducroc, R., Regnault, B., Kun Tan, C., Duszka, K., Burcelin, R., Wahli, W., Sansonetti, P. J., & Pédron, T. (2016). High-fat diet modifies the PPAR-γ pathway leading to disruption of microbial and physiological ecosystem in murine small intestine. Proceedings of the National Academy of Sciences, 113(40). https://doi.org/10.1073/pnas.1612559113
Van Kalkeren, C. A., Adam, T. C., & Blaak, E. E. (2026). Gut Microbiome-Associated Effects of Plant-Based Diets on Glucose Homeostasis, Body Composition, and Cognitive Function: A Scoping Review. Advances in Nutrition, 17(4), 100610. https://doi.org/10.1016/j.advnut.2026.100610
Wang, P.-X., Deng, X.-R., Zhang, C.-H., & Yuan, H.-J. (2020). Gut microbiota and metabolic syndrome. Chinese Medical Journal, 133(7), 808–816. https://doi.org/10.1097/CM9.0000000000000696
Zhou, W., Xu, H., Zhan, L., Lu, X., & Zhang, L. (2019). Dynamic Development of Fecal Microbiome During the Progression of Diabetes Mellitus in Zucker Diabetic Fatty Rats. Frontiers in Microbiology, 10, 232. https://doi.org/10.3389/fmicb.2019.00232
Zmora, N., Suez, J., & Elinav, E. (2019). You are what you eat: Diet, health and the gut microbiota. Nature Reviews Gastroenterology & Hepatology, 16(1), 35–56. https://doi.org/10.1038/s41575-018-0061-2