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Abstract

Dementia is defined by the progressive and sustained declined in cognitive function. Brain athropy, vascular disease of the brain, and brain mass are the most prevalent manifestations of dementia. Further, strong evidence revealed DM (Diabetes Melitus) and Hypertension as prominent risk factors. This results from cellular dysmetabolism and structural damage of the brain. Structural imaging should be performed in the assessment of dementia to established the subtype diagnosis. The aim of the present study was to investigate the pathologic features of the brain using MRI Brain on patient with dementia in Dr Moewardi Hospital, Surakarta. A quantitative descriptive was conducted in patients suffering from dementia undergoing MRI Brain in Dr Moewardi hospital, Surakarta from April 2022 to October 2023. During this study period, there were 11 patients included in our study were diagnosed with vascular dementia (n=9 ; 81.8%) and alzheimer dementia (n=2 ; 18.2%). It is being observed that vascular disease of the brain e.g. infark or ischemia was present in all participants (n=11 ; 100%). Brain athropy occured in 8 patients (72.7%) particularly medial- temporal lobe atrophy (n=4 ; 50%), parietal lobe atrophy (n=1 ; 12.5%), and cortical atrophy (n=5 ; 62.5%). Two incorporated cases observed with parietal and medial-temporal lobe atrophy (n=1) and medial-temporal and cortical atrophy (n=1). No case of brain mass observed. Diagnostically, hypertension presents in 10 (90.1%) patients and 1 (9.1%) patient associated with DM type 2. Dementia associated pathological features of the brain caused by cellular dysmetabolism and structural damage of the brain.

Keywords

Dementia, Brain pathology, Neuroimaging

Article Details

References

  1. Duong, S., Patel, T., & Chang, F. (2017). Dementia. Canadian Pharmacists Journal/Revue Des Pharmaciens Du Canada, 150(2), 118–129.
  2. Rizzi, L., Rosset, I., & Roriz-Cruz, M. (2014). Global Epidemiology of Dementia: Alzheimer’s and vascular types. BioMed Research International, 2014, 1–8.
  3. Cohen, M. (2015). Dementia 101. Neurology
  4. Now, 11(6), 44–51.
  5. Wolters, F. J., & Ikram, M. A. (2019). Epidemiology of Vascular Dementia. Arteriosclerosis, Thrombosis, and Vascular Biology, 39(8), 1542– 1549.
  6. Mossanen Parsi, M., Duval, C., & Ariëns, R. A. (2021). Vascular dementia and crosstalk between the complement and coagulation systems. Frontiers in Cardiovascular Medicine, 8.
  7. Noble, J. McC., Canoll, P., & Honig, L. S. (2005). Brain tumor-associated dementia. Science of Aging Knowledge Environment, 2005(34).
  8. Staffaroni, A., Elahi, F., McDermott, D., Marton, K., Karageorgiou, E., Sacco, S., Paoletti, M., Caverzasi, E., Hess, C., Rosen, H., & Geschwind, M. (2017). Neuroimaging in dementia. Seminars in Neurology, 37(05), 510–
  9. (2020). Diagnosis and Management in Dementia.
  10. Yaffe, K., & Zeki Al Hazzouri, A. (2016). Epidemiology and risk factors for dementia. The Behavioral Neurology of Dementia, 44–56.
  11. Choo, I. H., Lee, D. Y., Oh, J. S., Lee, J. S., Lee,
  12. D. S.,Song, I. C., Youn, J. C., Kim, S. G., Kim,
  13. K. W., Jhoo, J. H., & Woo, J. I. (2010). Posterior cingulate cortex atrophy and regional cingulum disruption in mild cognitive impairment and alzheimer’s disease. Neurobiology of Aging, 31(5), 772–779.
  14. Yamauchi, H. (2000). Comparison of the pattern of atrophy of the corpus callosum in frontotemporal dementia, progressive supranuclear palsy, and alzheimer’s disease.
  15. Journal of Neurology, Neurosurgery & Psychiatry, 69(5), 623–629.
  16. Pedraza, M. I., de Lera, M., Bos, D., Calleja, A. I., Cortijo, E., Gómez-Vicente, B., Reyes, J., Coco- Martín, M. B., Calonge, T., Agulla, J., Martínez-Pías, E., Talavera, B., Pérez-Fernández, S., Schüller, M., Galván, J., Castaño, M., Martínez-Galdámez, M., & Arenillas, J. F. (2020). Brain atrophy and the risk of futile endovascular reperfusion in acute ischemic stroke. Stroke, 51(5), 1514– 1521.
  17. Furtner, J., & Prayer, D. (2021). Neuroimaging in dementia. Wiener Medizinische Wochenschrift, 171(11–12), 274–281.
  18. Pasquier, F., Leys, D., Weerts, J. G. E., Mounier- Vehier, F., Barkhof, F., & Scheltens, P. (1996). Inter- and Intraobserver reproducibility of cerebral atrophy assessment on MRI scans with hemispheric infarcts. European Neurology, 36(5), 268–272.
  19. Acute cerebral ischemia-infarction. (2016). Imaging in Neurology, 96.
  20. Macfarlane, R. G., Wroe, S. J., Collinge, J., Yousry, T. A., & Jager, H. R. (2006). Neuroimaging findings in human prion disease. Journal of Neurology, Neurosurgery & Psychiatry, 78(7), 664–670.
  21. Błaszczyk, J. W. (2022). Pathogenesis of dementia. International Journal of Molecular Sciences, 24(1), 543.