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Abstract

Respiratory disorders often require intensive care management and empirical antibiotic therapy, which may lead to inappropriate use. This study aimed to evaluate the rationality of antibiotic use in the Intensive Care Unit (ICU) of Pandega Pangandaran Regional Hospital in 2023 based on the Gyssens criteria and to measure the quantity of antibiotic consumption using the ATC/DDD method recommended by the World Health Organization. A mixed-methods design was applied, utilizing retrospective data from medical records. The Gyssens criteria were employed for qualitative evaluation, while the ATC/DDD method assessed quantitative consumption. Consecutive sampling was used to select ICU patients who received antibiotic therapy. The analysis revealed that 33.8% of antibiotic prescriptions were rational (category 0), while irrational use was identified in category IIIB (duration too short, 23.8%), category IVA (more effective alternatives available, 32.5%), and category IVC (less expensive alternatives available, 10.0%). Quantitative analysis showed that levofloxacin had the highest consumption rate (56.48 DDD/100 patient-days), followed by ceftriaxone (46.40 DDD/100 patient-days). These findings indicate that antibiotic prescribing practices in the ICU were not fully rational, primarily due to the absence of culture and sensitivity testing. Strengthening antimicrobial stewardship and incorporating microbiological results into prescribing decisions are essential to optimize antibiotic use and reduce resistance risks.

Keywords

Antibiotics; Rational use; Intensive Care; Gyssens; ATC/DDD

Article Details

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