Main Article Content
Abstract
Generalized anxiety disorder (GAD) is a chronic condition characterized by excessive, difficult-to-control worry accompanied by somatic hyperarousal that can impair daily functioning. Comorbidity with mood–psychotic spectrum disorders, such as schizoaffective disorder, often increases symptom burden, complicates pharmacologic management, and raises the risk of relapse. These challenges have led to growing interest in adjunctive nonpharmacological approaches for managing residual anxiety, including acupuncture, which is hypothesized to influence glutamatergic signaling and autonomic regulation. We report a 38-year-old man with schizoaffective disorder, depressive subtype, and comorbid GAD who underwent 12 sessions of adjunctive acupuncture. The protocol combined scalp acupuncture with auricular laser acupuncture, targeting anxiety as the primary therapeutic focus. Post-treatment assessments demonstrated a clinically meaningful reduction in anxiety severity on the Hamilton Anxiety Rating Scale (HAM-A). Improvements were also observed in depressive symptoms (Hamilton Depression Rating Scale, HAM-D) and sleep quality (Pittsburgh Sleep Quality Index, PSQI), with no reported adverse events. This case suggests acupuncture may be a feasible complementary intervention for GAD, warranting further controlled studies.
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References
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- Baik, S. Y., & Newman, M. G. (2023). Generalized anxiety disorder. Encyclopedia of Mental Health, Third Edition: Volume 1-3. https://doi.org/10.1016/B978-0-323-91497-0.00264-2
- Bosch, P., Noort, M. van den, Staudte, H., & Lim, S. (2015). Schizophrenia and depression : a systematic review of the effectiveness and the working mechanism behind acupuncture. Explore, 281–291.
- Bruska, M., Dominiak, M., Kocherova, I., Bryja, A., Mozdziak, P., Hiroshi, T., Skiba, I., & Shibli, J. A. (2020). Photobiomodulation — Underlying Mechanism and Clinical Applications. Journal of Clinical Medicine.
- Buysse, D. J., Reynolds, C. F., Monk, T. H., Berman, S. R., & Kupfer, D. J. (1989). The Pittsburgh sleep quality index: A new instrument for psychiatric practice and research. Psychiatry Research.
- Chand, S. P., & Marwaha, R. (2025). Anxiety. In StatPearls. StatPearls Publishing. https://www.ncbi.nlm.nih.gov/books/NBK470361/
- Hamilton, M. (1959). The assessment of anxiety states by rating. British Journal of Medical Psychology. https://doi.org/10.1111/j.2044-8341.1959.tb00467.x
- Hamilton, M. (1960). A rating scale for depression. Journal of Neurology Neurosurgery Psychiatry. https://doi.org/doi: 10.1136/jnnp.23.1.56.
- Huang, C., Lan, D., Zhang, P., Dong, Y., Chang, R., Lao, J., & Li, Z. (2023). A Meta-Analysis on the Efficacy of Acupuncture as an Adjuvant Therapy for Schizophrenia. Neuropsychiatric Disease and Treatment. https://doi.org/10.2147/NDT.S428518
- Hui, K. K. S., Marina, O., Liu, J., Rosen, B. R., & Kwong, K. K. (2010). Acupuncture, the limbic system, and the anticorrelated networks of the brain. Autonomic Neuroscience: Basic and Clinical. https://doi.org/10.1016/j.autneu.2010.03.022
- Kessler, R. C., Angermeyer, M., Anthony, J. C., Graaf, R. De, Demyttenaere, K., Gasquet, I., Girolamo, G. De, Gluzman, S., Gureje, O., Haro, J. M., Kawakami, N., Karam, A., Levinson, D., Mora, M. E. M., Browne, M. A. O., Posada-Villa, J., Stein, D. J., Tsang, C. H. A., Aguilar-Gaxiola, S., … Ustun, T. B. (2007). Lifetime prevalence and age-of-onset distributions of mental disorders in the World Health Organization’s World Mental Health Survey Initiative. World Psychiatry.
- Kinman, G. (2025). The Pittsburgh Sleep Quality Index: a brief review. Occupational Medicine. https://doi.org/10.1093/occmed/kqae121
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- Nogier, R. (2009). Auriculotherapy. Thieme.
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- Nurmiati Amir. (2021). Skizoafektif. In S. D. Elvira & G. Hadisukanto (Eds.), Buku Ajar Psikiatri (Edisi ke-3, pp. 223–227). Badan Penerbit Fakultas Kedokteran Universitas Indonesia.
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- Spranger Forte, A., Bento, A., & Gama Marques, J. (2023). Schizoaffective disorder in homeless patients: A systematic review. International Journal of Social Psychiatry. https://doi.org/10.1177/00207640221131247
- Temmingh, H., & Stein, D. J. (2015). Anxiety in Patients with Schizophrenia: Epidemiology and Management. CNS Drugs.
- Tu, C. H., MacDonald, I., & Chen, Y. H. (2019). The effects of acupuncture on glutamatergic neurotransmission in depression, anxiety, schizophrenia, and Alzheimer’s disease: A review of the literature. Frontiers in Psychiatry. https://doi.org/10.3389/fpsyt.2019.00014
- Wang, X. X., & Wang, R. zhong. (2023). Scalp acupuncture + dǎoyǐn to treat sudden deafness in a pregnant woman: A case report. World Journal of Acupuncture - Moxibustion. https://doi.org/10.1016/j.wjam.2022.04.003
- Wang, Y. (2009). Micro-Acupuncture in Practice. Churcill Livingstone Elsevier Inc.
- WHO. (2023). Anxiety diorders. https://www.who.int/news-room/fact-sheets/detail/anxiety-disorders#:~:text=An estimated 4%25 of the,care providers%2C and social stigma.
- Wy, T. J. P., & Saadabadi, A. (2022). Schizoaffective Disorder Pathophysiology. StatPearls. www.ncbi.nlm.nih.gov/books/NBK541012/
- Zhu, M. (1992). Zhu’s Scalp Acupuncture (First Edit). 8 Dragons.
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References
Amorim, D., Brito, I., Caseiro, A., Figueiredo, J. P., Pinto, A., Macedo, I., & Machado, J. (2022). Electroacupuncture and acupuncture in the treatment of anxiety - A double blinded randomized parallel clinical trial. Complementary Therapies in Clinical Practice. https://doi.org/10.1016/j.ctcp.2022.101541
Baik, S. Y., & Newman, M. G. (2023). Generalized anxiety disorder. Encyclopedia of Mental Health, Third Edition: Volume 1-3. https://doi.org/10.1016/B978-0-323-91497-0.00264-2
Bosch, P., Noort, M. van den, Staudte, H., & Lim, S. (2015). Schizophrenia and depression : a systematic review of the effectiveness and the working mechanism behind acupuncture. Explore, 281–291.
Bruska, M., Dominiak, M., Kocherova, I., Bryja, A., Mozdziak, P., Hiroshi, T., Skiba, I., & Shibli, J. A. (2020). Photobiomodulation — Underlying Mechanism and Clinical Applications. Journal of Clinical Medicine.
Buysse, D. J., Reynolds, C. F., Monk, T. H., Berman, S. R., & Kupfer, D. J. (1989). The Pittsburgh sleep quality index: A new instrument for psychiatric practice and research. Psychiatry Research.
Chand, S. P., & Marwaha, R. (2025). Anxiety. In StatPearls. StatPearls Publishing. https://www.ncbi.nlm.nih.gov/books/NBK470361/
Hamilton, M. (1959). The assessment of anxiety states by rating. British Journal of Medical Psychology. https://doi.org/10.1111/j.2044-8341.1959.tb00467.x
Hamilton, M. (1960). A rating scale for depression. Journal of Neurology Neurosurgery Psychiatry. https://doi.org/doi: 10.1136/jnnp.23.1.56.
Huang, C., Lan, D., Zhang, P., Dong, Y., Chang, R., Lao, J., & Li, Z. (2023). A Meta-Analysis on the Efficacy of Acupuncture as an Adjuvant Therapy for Schizophrenia. Neuropsychiatric Disease and Treatment. https://doi.org/10.2147/NDT.S428518
Hui, K. K. S., Marina, O., Liu, J., Rosen, B. R., & Kwong, K. K. (2010). Acupuncture, the limbic system, and the anticorrelated networks of the brain. Autonomic Neuroscience: Basic and Clinical. https://doi.org/10.1016/j.autneu.2010.03.022
Kessler, R. C., Angermeyer, M., Anthony, J. C., Graaf, R. De, Demyttenaere, K., Gasquet, I., Girolamo, G. De, Gluzman, S., Gureje, O., Haro, J. M., Kawakami, N., Karam, A., Levinson, D., Mora, M. E. M., Browne, M. A. O., Posada-Villa, J., Stein, D. J., Tsang, C. H. A., Aguilar-Gaxiola, S., … Ustun, T. B. (2007). Lifetime prevalence and age-of-onset distributions of mental disorders in the World Health Organization’s World Mental Health Survey Initiative. World Psychiatry.
Kinman, G. (2025). The Pittsburgh Sleep Quality Index: a brief review. Occupational Medicine. https://doi.org/10.1093/occmed/kqae121
Konstantakopoulos, G., Masdrakis, V. G., Markianos, M., & Oulis, P. (2013). On the differential diagnosis of anxious from nonanxious major depression by means of the hamilton scales. The Scientific World Journal, 2013. https://doi.org/10.1155/2013/294516
Kreisel, V., & Weber, M. (2012). A Practical Handbook Laser Acupuncture Successful Treatment Concepts (First Edit). Fuchtenbusch Verlag.
Lukman, P. R. (2017). Gangguan Cemas Menyeluruh. In S. D. Elvira & G. Hadisukanto (Eds.), Buku Ajar Psikiatri (Edisi Keti, pp. 284–288). Badan Penerbit Fakultas Kedokteran Universitas Indonesia.
MacDonald, A., & Demro, C. (2023). Schizophrenia: Presentation, Affect and Cognition, Pathophysiology and Etiology. In R. F. Krueger & P. H. Blaney (Eds.), Oxford Textbook of Psychopatology (pp. 332–351). Oxford Academic.
Maslim, R. (2019). Diagnosis Gangguan Jiwa Rujukan Ringkas dari PPDGJ-III, DSM-5, ICD-11. Bagian Ilmu Kedokteran Jiwa FK Unika Atma Jaya.
Nogier, R. (2009). Auriculotherapy. Thieme.
Noort, M. van den, Yeo, S., Lim, S., Lee, S.-H., Staudte, H., & Bosch, P. (2018). Acupuncture as Add-On Treatment of the Positive, Negative, and Cognitive Symptoms of Patients with Schizophrenia: A Systematic Review. Medicines. https://doi.org/10.3390/medicines5020029
Nurmiati Amir. (2021). Skizoafektif. In S. D. Elvira & G. Hadisukanto (Eds.), Buku Ajar Psikiatri (Edisi ke-3, pp. 223–227). Badan Penerbit Fakultas Kedokteran Universitas Indonesia.
Robinson, N. G. (2016). Interactive Medical Acupuncture Anatomy. Teton NewMedia.
Sabbagh Gol, A., Rezaei Ardani, A., Farahmand, S. K., Dadgarmoghaddam, M., Ghorani, V., Rezaei, S., & Khorsand, A. (2021). Additive effects of acupuncture in alleviating anxiety: A double-blind, three-arm, randomized clinical trial. Complementary Therapies in Clinical Practice. https://doi.org/10.1016/j.ctcp.2021.101466
Spranger Forte, A., Bento, A., & Gama Marques, J. (2023). Schizoaffective disorder in homeless patients: A systematic review. International Journal of Social Psychiatry. https://doi.org/10.1177/00207640221131247
Temmingh, H., & Stein, D. J. (2015). Anxiety in Patients with Schizophrenia: Epidemiology and Management. CNS Drugs.
Tu, C. H., MacDonald, I., & Chen, Y. H. (2019). The effects of acupuncture on glutamatergic neurotransmission in depression, anxiety, schizophrenia, and Alzheimer’s disease: A review of the literature. Frontiers in Psychiatry. https://doi.org/10.3389/fpsyt.2019.00014
Wang, X. X., & Wang, R. zhong. (2023). Scalp acupuncture + dǎoyǐn to treat sudden deafness in a pregnant woman: A case report. World Journal of Acupuncture - Moxibustion. https://doi.org/10.1016/j.wjam.2022.04.003
Wang, Y. (2009). Micro-Acupuncture in Practice. Churcill Livingstone Elsevier Inc.
WHO. (2023). Anxiety diorders. https://www.who.int/news-room/fact-sheets/detail/anxiety-disorders#:~:text=An estimated 4%25 of the,care providers%2C and social stigma.
Wy, T. J. P., & Saadabadi, A. (2022). Schizoaffective Disorder Pathophysiology. StatPearls. www.ncbi.nlm.nih.gov/books/NBK541012/
Zhu, M. (1992). Zhu’s Scalp Acupuncture (First Edit). 8 Dragons.
Zhu, M. Q., & Siu, M. (2007). Color Atlas of Zhu’s Scalp Acupuncture (English Ed). Zhu’s Neuro-Acupuncture Center, Inc.