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Abstract

Epilepsy is a chronic neurological disorder characterized by recurrent unprovoked seizures, which substantially impair quality of life through sleep disruption, cognitive deficits, and risk of sudden unexpected death. Pharmacotherapy with antiepileptic drugs remains the mainstay of treatment; however, long-term use may induce adverse effects. Non-pharmacological interventions such as acupuncture have been proposed as adjunctive or alternative therapies. In particular, thread-embedding acupuncture (TEA) has been explored for its potential efficacy in drug-resistant epilepsy (DRE). This review evaluates the evidence for TEA in epilepsy by analyzing recent randomized controlled trials. A patient-assessor blinded clinical trial involving 54 outpatients with DRE found that TEA produced significantly higher rates of satisfactory seizure control (≥50% reduction in seizure frequency) compared to sham TEA (37% vs 3.7%; p = 0.003). Moreover, TEA was associated with decreased heart rate and increased heart rate variability, suggesting modulation of autonomic nervous system activity. Current evidence suggests TEA maybe effective adjunct for reducing seizure burden in patients with DRE. Nonetheless, further large-scale, long-term randomized trials are warranted to confirm its effects, elucidate mechanisms (including neural, ionic, immunologic pathways), and define optimal treatment protocols.

Keywords

Acupuncture Thread-embedded Catgut Epilepsy

Article Details

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